For detailed information regarding drugs, contraindications and side effects, please visit Medline Plus Health Information and consult your doctor or pharmacist. Note: In case of emergency/ overdose the local poison control center can be reached at 1 (800) 222-1212.
It is not uncommon for individuals with PLS or HSP to experience symptoms of depression and even to develop clinical depression. Studies indicate that more than 80% of people with clinical depression can be treated successfully with medications.
There are several types of antidepressants. They differ in their side effects and, to some extent, in their level of effectiveness. No one type of medication for depression has been shown to be more effective than any other. The main difference between the types of medication (marketing and cost aside) is in the limitation of side effects.
Medications must be taken regularly for as many as eight weeks before the full therapeutic effect occurs. If there is little or no change after five to six weeks, a different medication may be considered. Medication is taken for a minimum of several months and may last up to a year or more.
Antidepressant medicines work by altering the level of certain chemicals in the brain that are responsible for transferring messages between brain cells. The dosage varies, depending on the type of drug, the person’s body chemistry, age and body weight. Dosages are generally started low and raised gradually until the desired effect is reached without troublesome side effects.
Antidepressants are divided into three classes:
Though the tricyclics are as effective in treating depression as the newer antidepressants, their side effects are usually more unpleasant. They are generally used as a second-line or third-line treatment.
Most of these medications affect two chemical neurotransmitters, norepinephrine and serotonin. There are many generics available:
MAOIs are effective for some people with major depression who do not respond to other antidepressants. They are also effective for the treatment of panic disorder and bipolar depression.
MAOIs include phenelzine (Nardil), tranylcypromine (Parnate), and isocarboxazid (Marplan). Because substances in certain foods, beverages, and medications can cause dangerous interactions when combined with MAOIs, people on these agents must adhere to dietary restrictions. This has deterred many clinicians and patients from using these medications.
Tetracyclic antidepressantsThese antidepressants stimulate norepinephrine and serotonin release. They also block two serotonin receptors that cause some of the side effects of SSRI’s (sexual problems, others) and causes less symptoms than the tricyclics (dry eyes, constipation). Medications include Ludiomil (Maprotiline) and Remeron (mirtazapine). Two other antidepressants that affect norepinephrine and serotonin are venlafaxine (Effexor) and nefazodone (Serzone).
Bupropion (Wellbutrin, Wellbutrin SR)Treats depression by affecting dopamine and norepinephrine, which are believed to help regulate your mood. Wellbutrin has not been associated with weight gain or sexual dysfunction.
Psychotherapy can be very helpful for people with severe or mild depression, and also in everyday coping with having a chronic illness. Please see Supportive counseling.
The CFC or Combined Federal Cam-paign is a fundraising campaign the Federal Government offers its employ-ees to participate with each year. It begins Sept 1st and goes through Dec 15th. Federal employees are allowed to pick from over 200 registered nonpro-fits to contribute to. Many CFC fairs will be held at Federal facilities throughout the campaign. This allows employees to learn about the nonprofits and make their selections.
Please let friends and family members who are Federal employees know they can choose the Spastic Paraplegia Foun-dation to donate to. The SPF CFC num-ber is 12554. The following are exam-ples of Federal employees: law enforce-ment, mail personnel, VA or Veteran’s Administration employees, Medicare, Medicaid, military and many types of governmental jobs. If donors want to know more, please have them log on to
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When Clinical Trials begin in 2017 it may require as many people as possible for the Clinical Trial to be effective. If you have HSP or PLS, please add your information to our data base so we can keep you informed. We are missing a lot people's email address, so if you just want to add your email address. just enter your name, address and email and we'll add it. That way, we will be able to reach you quickly at a lower cost. Your privacy is very important to us. We will never share any of your information with any individual or company without your permission.
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